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CCL7
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'''CCL7''' is a small cytokine known as a chemokine that is also known as Monocyte-specific chemokine 3 (MCP3). It is utilized by the body's immune system for chemotaxis, or the movement of cells in response to chemical stimuli. CCL7 specifically attracts monocytes, and to a lesser extent lymphocytes, neutrophils, and eosinophils. == Function == CCL7 is a member of the [[CC chemokine]] family, and its gene is located on the third chromosome (3p21) in humans. It is secreted by various cells, including [[leukocytes]] and [[tissue cells]], in response to inflammatory signals such as [[interleukin 1]] or [[lipopolysaccharide]]. CCL7 works by binding to several different types of [[G protein-coupled receptors]] on the surface of cells, including [[CCR1]], [[CCR2]], and [[CCR3]]. This binding triggers a response inside the cell, leading to chemotaxis. == Clinical significance == CCL7 has been implicated in several disease processes, including [[rheumatoid arthritis]], [[atherosclerosis]], and certain types of [[cancer]]. It is thought to contribute to the inflammatory response in these conditions by attracting immune cells to the site of disease. == See also == * [[CCL2]] * [[CCL3]] * [[CCL4]] * [[CCL5]] == References == <references /> [[Category:Chemokines]] [[Category:Cytokines]] [[Category:Immunology]] {{Chemokines}} {{Cytokines}} {{Immunology-stub}} {{No image}} __NOINDEX__
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