Editing A23187

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'''A23187''' is a mobile ion-carrier that forms a stable complex with divalent cations (ions with a charge of +2). It is most commonly used in scientific research to increase intracellular [[calcium]] levels. 

== History ==
A23187, also known as [[Calcimycin]], was first isolated in 1968 from ''[[Streptomyces chartreusensis]]''. It was initially identified as an antibiotic, but its ability to transport divalent cations across biological membranes has made it a valuable tool in the study of cellular processes.

== Structure and Function ==
A23187 is a [[diterpene]] compound with a complex ring structure. It forms a neutral complex with divalent cations, particularly calcium, and transports them across biological membranes. The transport process is not dependent on the membrane potential, making A23187 a powerful tool for manipulating intracellular calcium levels.

== Applications ==
A23187 has been used in a wide range of biological research. It is often used to study the role of calcium in cellular processes, such as [[signal transduction]], [[muscle contraction]], and [[cell death]]. It has also been used to induce [[apoptosis]], or programmed cell death, in cancer cells.

== Safety ==
A23187 is toxic and should be handled with care. It can cause skin and eye irritation, and may be harmful if inhaled or swallowed.

== See Also ==
* [[Ionophore]]
* [[Calcium signaling]]
* [[Apoptosis]]

== References ==
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[[Category:Biochemistry]]
[[Category:Cell biology]]
[[Category:Pharmacology]]
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