Zoledronate
Zoledronate
Zoledronate (pronounced zo-le-DRO-nate), also known as zoledronic acid, is a type of bisphosphonate medication used to treat various bone diseases.
Pronunciation
Zoledronate is pronounced as zo-le-DRO-nate.
Etymology
The term "Zoledronate" is derived from the chemical name (1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid. The "Zol" part of the name is derived from the "imidazol" portion of the chemical name, and the "edronate" part is a common suffix for bisphosphonate drugs.
Usage
Zoledronate is used to treat a variety of bone diseases, including osteoporosis, Paget's disease, and high blood calcium levels (hypercalcemia) caused by cancer. It is also used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer, and to treat osteogenesis imperfecta.
Mechanism of Action
Zoledronate works by slowing down the process of bone breakdown (resorption) by inhibiting the activity of osteoclasts, the cells that are responsible for breaking down bone. This helps to maintain a healthy balance between bone formation and breakdown, and can help to strengthen the bones and reduce the risk of fractures.
Related Terms
- Bisphosphonate: A class of drugs that includes zoledronate, used to treat various bone diseases.
- Osteoporosis: A condition characterized by weak and brittle bones, which zoledronate is used to treat.
- Paget's disease: A condition that disrupts the normal cycle of bone renewal, which zoledronate is used to treat.
- Osteoclast: A type of cell that breaks down bone, the activity of which is inhibited by zoledronate.
External links
- Medical encyclopedia article on Zoledronate
- Wikipedia's article - Zoledronate
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