ZM447439
ZM447439 (pronounced: Z-M-four-four-seven-four-three-nine) is a selective and potent inhibitor of the Aurora kinase family, specifically Aurora B kinase. It is often used in scientific research to study the role of Aurora kinases in cell division and has potential therapeutic applications in the treatment of cancer.
Etymology
The term "ZM447439" is a systematic name derived from the compound's development code in the laboratories of AstraZeneca. The "ZM" prefix is an internal code used by the company, while the numbers "447439" are a unique identifier for this specific compound.
Pharmacology
ZM447439 works by inhibiting the activity of Aurora kinases, a family of enzymes that play a crucial role in the process of cell division. By blocking these enzymes, ZM447439 can disrupt the normal process of cell division, leading to cell death. This makes it a potential candidate for use in cancer therapy, as it could selectively kill rapidly dividing cancer cells.
Related Terms
- Aurora kinase: A family of enzymes that play a crucial role in the process of cell division.
- Aurora B kinase: A specific member of the Aurora kinase family that is the primary target of ZM447439.
- Cell division: The process by which a single cell divides into two daughter cells.
- Cancer: A group of diseases characterized by uncontrolled cell division and the potential to invade or spread to other parts of the body.
See Also
External links
- Medical encyclopedia article on ZM447439
- Wikipedia's article - ZM447439
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