Vesicular monoamine transporter 1
Vesicular Monoamine Transporter 1 (VMAT1)
Vesicular Monoamine Transporter 1 (VMAT1), pronounced as /vɛˈsɪkjʊlər moʊˈnəmiːn trænˈspɔːrtər wʌn/, is a protein that in humans is encoded by the SLC18A1 gene. The term originates from the Latin vesicula meaning "small vessel" and the Greek monoamine referring to a type of chemical messenger.
Function
VMAT1 is a membrane protein that transports monoamines—including neurotransmitters such as dopamine, serotonin, norepinephrine, and epinephrine—from cellular cytosol into synaptic vesicles. This process is known as vesicular monoamine transport.
Clinical Significance
Alterations in VMAT1 function have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and depression.
Pharmacology
Several drugs, including reserpine and tetrabenazine, work by inhibiting VMAT1, thereby affecting monoamine storage and neurotransmission.
See Also
References
External links
- Medical encyclopedia article on Vesicular monoamine transporter 1
- Wikipedia's article - Vesicular monoamine transporter 1
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