Tumor budding

Tumor budding is a phenomenon observed in certain types of cancer where individual cells, or small clusters of cells, break away from the main tumor mass and invade the surrounding tissue. It is considered a sign of aggressive tumor behavior and is associated with a higher risk of cancer recurrence and poor prognosis.

Pronunciation

Tumor budding is pronounced as /ˈtjuːmər ˈbʌdɪŋ/.

Etymology

The term "tumor budding" is derived from the English words "tumor", which comes from the Latin tumere meaning "to swell", and "budding", which refers to the process in which a new, smaller structure develops from an existing one.

Definition

Tumor budding is defined by the presence of individual cells or small clusters of up to four cells at the invasive front of the tumor. These cells have detached from the main tumor mass and are thought to represent an early stage in the process of metastasis.

Clinical significance

Tumor budding is considered a significant prognostic factor in many types of cancer, including colorectal cancer, pancreatic cancer, and esophageal cancer. It is associated with a higher risk of lymph node metastasis, distant metastasis, and cancer recurrence. The presence of tumor budding is also linked to a poorer response to chemotherapy and radiotherapy.

Related terms

• Cancer
• Metastasis
• Chemotherapy
• Radiotherapy
• Colorectal cancer
• Pancreatic cancer
• Esophageal cancer

External links

• Medical encyclopedia article on Tumor budding
• Wikipedia's article - Tumor budding

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