Transient abnormal myelopoiesis
Transient abnormal myelopoiesis | |
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Term | Transient abnormal myelopoiesis |
Short definition | Transient abnormal myelopoiesis - (pronounced) (TRAN-zee-ent ab-NOR-mul MY-eh-loh-poy-EE-sis) disease of the bone marrow that can occur in newborn babies with Down syndrome. It is characterized by abnormal, immature haematopoietic cells in the blood and bone marrow (particularly the cells involved in the formation of platelets). |
Type | Cancer terms |
Specialty | Oncology |
Language | English |
Source | NCI |
Comments |
Transient abnormal myelopoiesis - (pronounced) (TRAN-zee-ent ab-NOR-mul MY-eh-loh-poy-EE-sis) disease of the bone marrow that can occur in newborn babies with Down syndrome. It is characterized by abnormal, immature haematopoietic cells in the blood and bone marrow (particularly the cells involved in the formation of platelets). The liver may also be larger than normal. Transient abnormal myelopoiesis is caused by mutations (changes) in a gene called GATA1. The transient abnormal myelopoiesis usually goes away on its own within the first 3 months of life. Sometimes transient abnormal myelopooesis causes serious or life-threatening problems, such as: B. bleeding problems, infections, heart, kidney and liver failure and an abnormal accumulation of fluid in the tissues that cover the organs in the body. Infants with transient abnormal myelopoiesis are at increased risk of developing acute myeloid leukemia (AML) before the age of 3 years. Also called TAM, TMD, transient leukemia and transient myeloproliferative disease
External links
- Medical encyclopedia article on Transient abnormal myelopoiesis
- Wikipedia's article - Transient abnormal myelopoiesis
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