Transferrin saturation
Transferrin Saturation
Transferrin saturation (pronounced as trans-ferr-in sat-u-ra-tion), also known as TSAT, is a medical term used to measure the percentage of transferrin that is saturated with iron in the bloodstream.
Etymology
The term "transferrin saturation" is derived from the protein "transferrin" which is responsible for the transportation of iron in the body, and "saturation" which refers to the extent to which the transferrin is filled or saturated with iron.
Definition
Transferrin saturation is a calculation derived from the serum iron concentration and the total iron-binding capacity (TIBC). It is expressed as a percentage and provides an estimate of the proportion of the iron-binding sites of transferrin that are occupied by iron.
Calculation
The calculation for transferrin saturation is as follows:
TSAT (%) = (Serum Iron (μg/dL) / Total Iron Binding Capacity (μg/dL)) x 100
Clinical Significance
Transferrin saturation is an important diagnostic tool in the evaluation of iron status. It is used in the diagnosis and monitoring of iron deficiency anemia and iron overload conditions such as hemochromatosis. A low transferrin saturation indicates iron deficiency, while a high transferrin saturation suggests iron overload.
Related Terms
External links
- Medical encyclopedia article on Transferrin saturation
- Wikipedia's article - Transferrin saturation
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