Thiolutin
Thiolutin
Thiolutin (pronounced: /ˌθaɪoʊˈluːtɪn/) is a sulfur-containing antibiotic that is derived from the bacterium Streptomyces azureus. It is known for its inhibitory effects on DNA and RNA synthesis, particularly in bacteria and yeast.
Etymology
The term "Thiolutin" is derived from the Greek words "thio" meaning sulfur, and "lutin" which is a reference to the yellow color of the compound. The name reflects the sulfur content and the yellow color of the antibiotic.
Mechanism of Action
Thiolutin inhibits the synthesis of DNA and RNA by binding to the RNA polymerase, a key enzyme involved in the transcription process. This binding prevents the enzyme from adding new nucleotides to the growing RNA chain, thus halting the transcription process and inhibiting protein synthesis.
Uses
Thiolutin is primarily used in research as a tool to study the mechanisms of transcription and translation. It is also used in the study of gene expression and protein synthesis. In addition, it has potential applications in the treatment of bacterial and yeast infections due to its antibiotic properties.
Related Terms
- Antibiotic
- Transcription (genetics)
- Translation (biology)
- RNA polymerase
- Gene expression
- Protein synthesis
External links
- Medical encyclopedia article on Thiolutin
- Wikipedia's article - Thiolutin
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