T790M
T790M
T790M (pronounced T-seven-ninety-M) is a specific mutation found in the epidermal growth factor receptor (EGFR) gene. This mutation is often associated with non-small cell lung cancer (NSCLC) and is known to cause resistance to certain EGFR inhibitors.
Etymology
The term "T790M" is derived from the specific nature of the mutation. The "T" stands for threonine, the amino acid that is normally present at position 790 in the EGFR protein. The "790" refers to the position of the amino acid in the protein sequence. The "M" stands for methionine, the amino acid that replaces threonine in the mutated form of the protein.
Pronunciation
The term "T790M" is pronounced as "T-seven-ninety-M".
Related Terms
- EGFR: Epidermal Growth Factor Receptor, a protein found on the surface of some cells to which epidermal growth factor binds, causing the cells to divide.
- Mutation: A change in the DNA sequence of a gene.
- Non-small cell lung cancer (NSCLC): The most common type of lung cancer.
- EGFR inhibitors: A type of drug that blocks the action of a protein in the body that can affect tumor cell growth.
- Threonine: An amino acid, a building block of proteins.
- Methionine: An amino acid, a building block of proteins.
External links
- Medical encyclopedia article on T790M
- Wikipedia's article - T790M
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