Solifenacin

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Information about Solifenacin

Solifenacin is an anticholinergic and antispasmodic agent used to treat urinary incontinence and the overactive bladder syndrome.

Liver safety of Solifenacin

Solifenacin has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

Mechanism of action of Solifenacin

Solifenacin (soe" li fen' a sin) is an anticholinergic agent that inhibits muscarinic actions of acetylcholine on autonomic nerve endings, decreasing secretions and inhibiting gastrointestinal and bladder motility. Solifenacin increases the bladder capacity and decreases contractions and the urgency of urination.

FDA approval information for Solifenacin

Solifenacin was approved for use in the United States in 2004 and it remains in clinical use. Current indications are for treatment of overactive bladder and symptoms of urgency and urinary frequency.

Dosage and administration for Solifenacin

It is available in tablets of 5 and 10 mg under the brand name VESIcare. The recommended adult oral dose is 5 to 10 mg once daily.

Side effects of Solifenacin

Common side effects are those of parasympathetic stimulation and include dryness of the mouth and eyes, decreased sweating, headache, visual blurring, constipation, urinary retention, restlessness, confusion and hallucinations. anticholinergic agents can precipitate acute narrow angle glaucoma and acute urinary retention.


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