SIVA1
SIVA1
SIVA1 (pronounced: /siːvə wʌn/), also known as SIVA1 apoptosis-inducing factor, is a protein that in humans is encoded by the SIVA1 gene. The term SIVA1 is derived from the Sanskrit word "Siva", the Hindu god associated with destruction and regeneration, and the number 1, indicating it as the first identified member of this protein family.
Function
The SIVA1 protein is known to play a significant role in the process of apoptosis, or programmed cell death. It is a crucial component in maintaining the balance of cell growth and death within the body. Abnormalities in the function or expression of SIVA1 have been linked to various diseases, including cancer.
Structure
The SIVA1 protein is a small protein, consisting of 191 amino acids. It contains a death domain (DD), a common feature of proteins involved in apoptosis, and a SIVA1 domain, unique to this protein family.
Clinical Significance
Alterations in the SIVA1 gene have been associated with several types of cancer, including breast cancer, lung cancer, and colorectal cancer. It is thought that these alterations may disrupt the normal process of apoptosis, leading to uncontrolled cell growth and the development of tumors.
Related Terms
External links
- Medical encyclopedia article on SIVA1
- Wikipedia's article - SIVA1
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