From WikiMD
Jump to navigation Jump to search
Other languages:

Information about Rabeprazole

Rabeprazole is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity used in the therapy of gastroesophageal reflux and peptic ulcer disease. 

Liver safety of Rabeprazole

Rabeprazole therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a rare cause of clinically apparent liver injury.

Mechanism of action of Rabeprazole

Rabeprazole (ra bep' ra zole), like other PPIs, binds to and inactivates the H+/K+-ATPase of gastric parietal cells, causing inhibition of the proton pump that transports H+ into the gastric lumen, the final common step in gastric acid production.  Rabeprazole is a prodrug and is converted to the active form in the acidic secretory canaliculi of parietal cells.  Because the inhibition is irreversible, acid secretion is suppressed for 24 to 48 hours, until new proton pump molecules have been synthesized and transported to the cell membrane. 

FDA approval information for Rabeprazole

Rabeprazole was the third PPI approved for use in the United States (1999) and is widely used in the therapy of acid-peptic disease, including duodenal and gastric ulcer disease and gastroesophageal reflux. 

Dosage and administration for Rabeprazole

Rabeprazole is available in delayed release tablets of 20 mg in generic forms and under the brand name Aciphex.  The typical dose for duodenal ulcer disease is 20 mg once daily for 4 to 8 weeks, with similar doses for long term maintenance therapy.  Twice daily doses are used for more severe cases of gastrointestinal reflux and peptic ulcer disease, and doses of up to 120 mg daily for Zollinger-Ellison syndrome. 

Side effects of Rabeprazole

Rabeprazole is very well tolerated.  Side effects are uncommon and usually mild; they may include nausea, vomiting, abdominal discomfort, constipation, diarrhea, flatulence, skin rash, headaches and dizziness.  Severe side effects are rare but can include hypersensitivity reactions.  Long-term use of rabeprazole may be associated with bone fractures, acute interstitial nephritis, lupus erythematosus, vitamin B12 deficiency and hypomagnesemia

The antiulcer agents in clinical use

Proton Pump Inhibitors

Selective Histamine Type 2 Receptor Antagonists or H2 Blockers

Cost and Coupons - Rabeprazole

Reviews for Rabeprazole

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Articles on Rabeprazole

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Rabeprazole

Drug classes

WikiMD Resources for Rabeprazole


Most recent articles

Most cited

Review articles

Articles on Rabeprazole in N Eng J Med, Lancet, BMJ

Media Rabeprazole

Powerpoint slides

Podcasts and MP3's


Evidence Based Medicine

Cochrane Collaboration

Clinical Trials

Ongoing Trials on Rabeprazole

Trial results on Rabeprazole

Clinical Trials on Rabeprazole at Google

Books and news

Books on Rabeprazole

Rabeprazole in the news

Commentary Rabeprazole

Blogs on Rabeprazole

Patient Resources / Community

Patient resources

Discussion groups

Patient Handouts

Other resources

Social Media

YouTube videos

W8MD Weight Loss, Sleep & MedSpa

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U |V | W | X | Y | Z

Ad. Tired of being overweight? W8MD's insurance weight loss program can HELP* | Lose weight King of Prussia, PA | Lose weight NYC | Lose weight NJ | Lose weight Philadelphia Advertise
Other languages:

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary for weight loss from our sponsors.

Our sponsors WikiMD is supported by W8MD weight loss, sleep and medical aesthetic centers.