Progeroid syndromes
Progeroid syndromes
Progeroid syndromes (/proʊˈdʒɪərɔɪd ˈsɪndroʊmz/) are a group of rare genetic disorders which mimic physiological aging, making affected individuals appear to be older than they are. The term "progeroid" is derived from the Greek words "pro" (meaning "before" or "premature") and "geras" (meaning "old age").
Classification
Progeroid syndromes can be broadly classified into two categories: Segmental progeroid syndromes and Generalized progeroid syndromes. Segmental progeroid syndromes are characterized by the premature aging of specific organ systems or tissues, while generalized progeroid syndromes involve the premature aging of the entire organism.
Examples
Some examples of progeroid syndromes include Hutchinson-Gilford Progeria Syndrome (HGPS), Werner syndrome, and Cockayne syndrome. These conditions are characterized by features such as short stature, low body weight, hair loss, skin changes, and in some cases, a shortened lifespan.
Genetics
Progeroid syndromes are typically caused by mutations in genes that are involved in the maintenance of DNA integrity, DNA repair, and cellular senescence. For example, mutations in the LMNA gene cause Hutchinson-Gilford Progeria Syndrome, while mutations in the WRN gene cause Werner syndrome.
Treatment
There is currently no cure for progeroid syndromes. Treatment is symptomatic and supportive, and may include physical therapy, nutritional support, and management of any associated medical conditions.
See also
External links
- Medical encyclopedia article on Progeroid syndromes
- Wikipedia's article - Progeroid syndromes
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