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Prochlorperazine
Information about Prochlorperazine
Prochlorperazine is a phenothiazine used primarily as an antiemetic agent.
Liver safety of Prochlorperazine
In rare instances, prochlorperazine can cause clinically apparent acute and chronic cholestatic liver injury.
Mechanism of action of Prochlorperazine
Prochlorperazine (proe" klor per' a zeen) is a tricyclic aliphatic phenothiazine which acts by postsynaptic inhibition of dopamine receptors. Prochlorperazine has other peripheral and central nervous system effects, producing both alpha adrenergic stimulation and blocking histamine- and serotonin-mediated effects. Prochlorperazine is indicated primarily for the therapy of nausea and vomiting.
Other clinical effects
Prochlorperazine also has antianxiety and antipsychotic effects, but is used less commonly for these indications compared to the major phenothiazines such as chlorpromazine, fluphenazine, perphenazine, thioridazine and trifluoperazine.
FDA approval
Prochlorperazine was FDA approved for use in the United States in 1956 and is still widely used in therapy of nausea and vomiting.
Availability
Prochlorperazine is available in generic forms as tablets of 5, 10 and 25 mg, in long acting capsules of 15 mg, as an oral solution of 5 mg/ 5 mL, as suppositories of 2.5, 5 and 25 mg, and in parenteral forms.
Brand names
Prochlorperazine is also available under the brand names of Compazine and Compro.
Dosage and administration for Prochlorperazine
Typical doses for nausea are 5 to 10 mg three to four times daily.
Side effects of Prochlorperazine
Common side effects are similar to other phenothiazines and include drowsiness, dizziness, headache, blurred vision, dry mouth, constipation, tremor, restlessness, muscle spasms and weight gain.
Antipsychotic agents
First Generation
- Other
Second Generation (Atypicals)
- Aripiprazole, Asenapine, Brexpiprazole, Cariprazine, Clozapine, Iloperidone, Lurasidone, Olanzapine, Paliperidone, Pimavanserin, Quetiapine, Risperidone, Ziprasidone
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Reviews for Prochlorperazine
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Latest research (Pubmed)
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