Pioglitazone/metformin
Pioglitazone/Metformin
Pioglitazone/Metformin (pronunciation: pye-oh-GLI-ta-zone/met-FOR-min) is a combination medication used in the treatment of Type 2 diabetes.
Etymology
The term Pioglitazone is derived from its chemical name 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]benzylidene]-3-thioxo-2-thiazolidinone. Metformin is derived from the French term Metformine, which is a derivative of the plant Galega officinalis, known for its anti-diabetic properties.
Usage
Pioglitazone/Metformin is used to control high blood sugar in people with Type 2 diabetes. This medication is used when diet and exercise alone does not result in the adequate control of blood sugar.
Mechanism of Action
Pioglitazone is a thiazolidinedione that decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Metformin is a biguanide that improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose.
Side Effects
Common side effects of Pioglitazone/Metformin include headache, muscle pain, weight gain, and respiratory tract infections. Serious side effects may include lactic acidosis, heart failure, and bladder cancer.
Related Terms
External links
- Medical encyclopedia article on Pioglitazone/metformin
- Wikipedia's article - Pioglitazone/metformin
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