Phospholipase C

Phospholipase C

Phospholipase C (pronounced: fos-fo-li-pase C) is a class of enzymes that are important in cellular processes.

Etymology

The term "Phospholipase C" is derived from the type of bond it breaks in phospholipids (the glycerophosphate bond) and the letter "C" is used to differentiate it from other types of phospholipases.

Function

Phospholipase C is involved in signal transduction processes in the cell. It cleaves Phosphatidylinositol 4,5-bisphosphate (PIP2) into Inositol trisphosphate (IP3) and Diacylglycerol (DAG), both of which act as second messengers in the cell. IP3 triggers the release of calcium ions from the endoplasmic reticulum, while DAG activates Protein kinase C.

Related Terms

• Phospholipid
• Enzyme
• Cell biology
• Phosphatidylinositol 4,5-bisphosphate
• Inositol trisphosphate
• Diacylglycerol
• Calcium ion
• Endoplasmic reticulum
• Protein kinase C

External links

• Medical encyclopedia article on Phospholipase C
• Wikipedia's article - Phospholipase C

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