Osteitis fibrosa cystica
Osteitis Fibrosa Cystica
Osteitis fibrosa cystica (pronounced: os-tee-EYE-tis fy-BROH-suh SIS-ti-kuh), often referred to as Von Recklinghausen's disease of bone, is a skeletal disorder resulting from an overactivity of the parathyroid glands and the subsequent overproduction of parathyroid hormone (PTH).
Etymology
The term "Osteitis fibrosa cystica" is derived from the Greek words "osteon" meaning bone, "itis" indicating inflammation, "fibrosa" referring to fibrous tissue, and "cystica" denoting the presence of cysts. The condition was first described by German pathologist Friedrich Daniel von Recklinghausen, hence the alternative name "Von Recklinghausen's disease of bone".
Definition
Osteitis fibrosa cystica is characterized by the development of fibrous cysts within the bone structure. These cysts are filled with a brown, fibrous material, leading to the characteristic "brown tumors" of the disease. The condition is most commonly associated with hyperparathyroidism, a condition where the parathyroid glands produce too much PTH, leading to high levels of calcium in the blood.
Symptoms
Symptoms of osteitis fibrosa cystica may include bone pain, skeletal deformities, fractures, and kidney stones. Other symptoms related to hyperparathyroidism, such as fatigue, weakness, and depression, may also be present.
Diagnosis
Diagnosis of osteitis fibrosa cystica is typically based on a combination of clinical symptoms, blood tests showing elevated levels of PTH and calcium, and imaging studies such as X-rays or CT scans showing characteristic changes in the bones.
Treatment
Treatment of osteitis fibrosa cystica primarily involves addressing the underlying hyperparathyroidism, often through surgical removal of the overactive parathyroid glands. Medications to lower calcium levels in the blood may also be used.
Related Terms
External links
- Medical encyclopedia article on Osteitis fibrosa cystica
- Wikipedia's article - Osteitis fibrosa cystica
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