Netrin receptor DCC
Netrin receptor DCC
Netrin receptor DCC (pronounced: net-rin re-cep-tor D-C-C), also known as Deleted in Colorectal Cancer, is a protein that in humans is encoded by the DCC gene.
Etymology
The term "Netrin" is derived from the Sanskrit word "netr", which means "one who guides". The term "DCC" is an acronym for "Deleted in Colorectal Cancer", which is a reference to the gene's discovery during research into colorectal cancer.
Function
Netrin receptor DCC is a receptor for netrin, a protein involved in axon guidance. It plays a crucial role in the development of the nervous system by guiding the growth of axons towards their targets. The receptor is also implicated in the process of apoptosis (programmed cell death), particularly in the absence of netrin.
Related Terms
- Netrin: A family of proteins involved in axon guidance.
- Axon guidance: The process by which neurons send out axons to reach the correct targets.
- Apoptosis: A form of programmed cell death that occurs in multicellular organisms.
- Colorectal cancer: A cancer that starts in the colon or the rectum.
Clinical Significance
Mutations in the DCC gene have been associated with various types of cancer, including colorectal cancer. The gene is often deleted or mutated in colorectal cancer cells, hence its name. It is also being studied for its potential role in other diseases, such as neurodegenerative diseases and mental disorders.
External links
- Medical encyclopedia article on Netrin receptor DCC
- Wikipedia's article - Netrin receptor DCC
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