Nalbuphine

Nalbuphine (pronunciation: nal-BYOO-feen) is a semi-synthetic opioid used primarily in the management of moderate to severe pain. It is also used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.

Etymology

The term "Nalbuphine" is derived from "nalline" (an opioid antagonist) and "buphine" (from buprenorphine, a semi-synthetic opioid).

Pharmacology

Nalbuphine is a mixed agonist/antagonist analgesic of the phenanthrene series. It shares structural similarities with the widely used opioid antagonist, naloxone. It is 10 times as potent as morphine on a milligram basis.

Clinical Use

Nalbuphine is indicated for the relief of moderate to severe pain. It can also be used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.

Side Effects

Like other opioids, nalbuphine has potential side effects including sedation, sweating, nausea, vomiting, dizziness, and respiratory depression.

Related Terms

• Opioid
• Agonist
• Antagonist
• Analgesic
• Naloxone
• Morphine
• Buprenorphine

External links

• Medical encyclopedia article on Nalbuphine
• Wikipedia's article - Nalbuphine

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