NSG mouse
NSG Mouse
The NSG mouse (pronounced en-es-gee mouse), also known as the NOD scid gamma mouse, is a type of laboratory mouse that is commonly used in biomedical research.
Pronunciation
- NSG: /ɛn ɛs dʒiː/
- NOD scid gamma: /nɒd skɪd ɡæmə/
Etymology
The term "NSG mouse" is an acronym derived from the mouse's full scientific name, NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ. The "N" stands for "NOD" (Non-Obese Diabetic), the "S" stands for "scid" (severe combined immunodeficiency), and the "G" stands for "gamma" (referring to the gamma chain of the interleukin-2 receptor).
Description
The NSG mouse is a genetically engineered mouse strain that lacks a functional immune system. This makes it an ideal model for studying human diseases, including cancer, infectious diseases, and autoimmune disorders. The NSG mouse is also used for xenotransplantation studies, where human cells, tissues, or organs are transplanted into the mouse to study their function and behavior in a living organism.
Related Terms
- NOD Mouse: A strain of mouse that spontaneously develops type 1 diabetes and is used as a model for the human disease.
- SCID Mouse: A type of mouse with severe combined immunodeficiency, used in research to study the immune system and various diseases.
- Xenotransplantation: The process of grafting or transplanting organs or tissues between members of different species.
- Immunodeficiency: A state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent.
External links
- Medical encyclopedia article on NSG mouse
- Wikipedia's article - NSG mouse
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