Myelokathexis
Myelokathexis
Myelokathexis (pronounced: my-elo-kath-exis) is a rare hematological disorder characterized by the failure of neutrophils to enter the bloodstream from the bone marrow, resulting in severe neutropenia.
Etymology
The term "myelokathexis" is derived from the Greek words "myelos" meaning marrow and "kathexis" meaning retention. Thus, it literally translates to "retention in the marrow".
Definition
Myelokathexis is a form of chronic neutropenia characterized by the hyperplasia of mature neutrophils in the bone marrow and their failure to be released into the peripheral blood. This results in a severe decrease in circulating neutrophils, leading to an increased susceptibility to bacterial infections.
Symptoms
The primary symptom of myelokathexis is recurrent bacterial infections due to the lack of neutrophils in the bloodstream. Other symptoms may include fever, fatigue, and weight loss.
Diagnosis
Diagnosis of myelokathexis is typically made through a complete blood count (CBC) which shows a low neutrophil count. A bone marrow biopsy may also be performed to confirm the diagnosis.
Treatment
Treatment for myelokathexis typically involves the administration of granulocyte colony-stimulating factor (G-CSF) to stimulate the production and release of neutrophils from the bone marrow.
Related Terms
External links
- Medical encyclopedia article on Myelokathexis
- Wikipedia's article - Myelokathexis
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