Mipomersen
Mipomersen
Mipomersen (pronounced mi-po-mer-sen) is a therapeutic antisense oligonucleotide used in the treatment of homozygous familial hypercholesterolemia.
Etymology
The name "Mipomersen" is derived from the chemical structure of the drug, which is a modified antisense oligonucleotide. The "mi" stands for "modified", "po" for "poly", and "mersen" for "mers", which is a unit of measurement in chemistry referring to the number of repeating units in a polymer.
Usage
Mipomersen is used to lower low-density lipoprotein (LDL) cholesterol levels in patients with homozygous familial hypercholesterolemia, a rare genetic disorder that leads to extremely high cholesterol levels. It works by blocking the production of apolipoprotein B, a protein that carries cholesterol in the blood.
Related Terms
- Antisense oligonucleotide: A strand of nucleic acid that binds to and inhibits the function of a specific gene.
- Homozygous familial hypercholesterolemia: A genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL), in the blood.
- Low-density lipoprotein (LDL): A type of lipoprotein that carries cholesterol in the blood. High levels of LDL can lead to plaque buildup in the arteries and heart disease.
- Apolipoprotein B: A protein that carries cholesterol in the blood. Mipomersen works by blocking the production of this protein.
External links
- Medical encyclopedia article on Mipomersen
- Wikipedia's article - Mipomersen
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