- 1 Information about Mercaptopurine
- 2 Liver safety of Mercaptopurine
- 3 Mechanism of action of Mercaptopurine
- 4 FDA approval information for Mercaptopurine
- 5 Dosage and administration for Mercaptopurine
- 6 Side effects of Mercaptopurine
- 7 Cost and Coupons - Mercaptopurine
- 8 Reviews for Mercaptopurine
- 9 Articles on Mercaptopurine
- 10 Learn more about Mercaptopurine
- 11 Help WikiMD
Information about Mercaptopurine
Mercaptopurine (also referred to as 6-mercaptopurine or 6-MP) is a purine analogue that is effective both as an anticancer and an immunosuppressive agent, and is used to treat leukemia and autoimmune diseases as a corticosteroid-sparing agent.
Liver safety of Mercaptopurine
Mercaptopurine therapy is associated with a high rate of serum aminotransferase elevations which can be accompanied by jaundice. In addition, mercaptopurine has been linked to instances of clinically apparent acute liver injury and long term therapy to nodular regenerative hyperplasia.
Mechanism of action of Mercaptopurine
Mercaptopurine (mer kap" toe pure' een) is a purine analogue that acts as an antimetabolite by antagonism of purine metabolism which results in a general inhibition of DNA, RNA and subsequent protein synthesis. Mercaptopurine also has antiinflammatory and immunosuppressive activity, inhibiting the maturation of T cells and blocking delayed hypersensitivity reactions.
FDA approval information for Mercaptopurine
Mercaptopurine was introduced into use in the 1950s for the therapy of leukemia and lymphoma and was formally approved for use in the United States in 1953. It is still used in therapy of acute lymphocytic leukemia and off-label for autoimmune conditions such as Crohn’s disease.
Dosage and administration for Mercaptopurine
Mercaptopurine is available generically and under the brand name of Purinethol as tablets of 50 mg. The usual dose is 1 to 3 mg per kilogram or 50 to 150 mg daily, and it is typically given long term.
Side effects of Mercaptopurine
Cost and Coupons - Mercaptopurine
Reviews for Mercaptopurine
Articles on Mercaptopurine
- UpToDate on Mercaptopurine
- NIH NLH drug info on Mercaptopurine
- Read Wikipedia's article on Mercaptopurine
Learn more about Mercaptopurine
- Dailymed label info on Mercaptopurine
- Scientific articles on Mercaptopurine
- Images for Mercaptopurine
Find something you can improve? Join WikiMD as an an editor and help improve this page or others.
|Wikimedia Commons has media related to Drugs.|