Mecamylamine
Mecamylamine
Mecamylamine (pronounced meh-kah-MILL-ah-meen) is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors that was introduced in the 1950s as an anti-hypertensive drug.
Etymology
The term "Mecamylamine" is derived from its chemical name, N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine.
Usage
Mecamylamine has been used in the treatment of hypertension, and more recently, in combination with nicotine replacement therapies to aid in smoking cessation. It is also used in research to help understand the function of the nicotinic acetylcholine receptors.
Pharmacology
Mecamylamine works by blocking the effects of acetylcholine, a neurotransmitter in the brain. It does this by binding to the nicotinic acetylcholine receptors, preventing acetylcholine from binding and thus inhibiting the receptor's function.
Side Effects
Common side effects of Mecamylamine include dry mouth, blurred vision, and constipation. More serious side effects can include hallucinations, severe allergic reactions, and difficulty urinating.
Related Terms
External links
- Medical encyclopedia article on Mecamylamine
- Wikipedia's article - Mecamylamine
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