Massive perivillous fibrin deposition
Massive Perivillous Fibrin Deposition (pronunciation: mass-iv per-i-vil-lous fi-brin de-po-si-tion) is a rare placental disorder characterized by the extensive accumulation of fibrin, a protein involved in blood clotting, around the placental villi. The condition is associated with adverse pregnancy outcomes including fetal growth restriction, stillbirth, and recurrent pregnancy loss.
Etymology
The term "Massive Perivillous Fibrin Deposition" is derived from the Latin words 'massivus' meaning 'large or extensive', 'peri' meaning 'around', 'villus' meaning 'small, hair-like structure', and 'fibrin' which is a protein involved in blood clotting. 'Deposition' refers to the process of laying down or depositing a substance.
Pathophysiology
In Massive Perivillous Fibrin Deposition, excessive fibrin accumulates around the placental villi, the tiny, finger-like projections on the placenta that increase its surface area and enhance the exchange of nutrients and waste products between the mother and fetus. This accumulation can compromise the function of the placenta, leading to adverse pregnancy outcomes.
Clinical Presentation
Women with Massive Perivillous Fibrin Deposition may present with a history of recurrent pregnancy loss, intrauterine growth restriction, or stillbirth. The condition is often diagnosed through histopathological examination of the placenta following delivery or pregnancy loss.
Management and Prognosis
Management of Massive Perivillous Fibrin Deposition is challenging due to the lack of specific treatment options. Care is largely supportive and focuses on close monitoring of the pregnancy. The prognosis varies and is largely dependent on the extent of fibrin deposition and the associated impact on placental function.
Related Terms
External links
- Medical encyclopedia article on Massive perivillous fibrin deposition
- Wikipedia's article - Massive perivillous fibrin deposition
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