JAK-STAT signaling pathway
JAK-STAT signaling pathway
The JAK-STAT signaling pathway (pronounced: jak-stat signaling pathway) is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death, and tumor formation.
Etymology
The name "JAK-STAT" is derived from the names of the proteins involved: Janus kinase (JAK) and Signal Transducer and Activator of Transcription (STAT).
Function
The JAK-STAT signaling pathway is initiated when a cell releases a substance (such as a hormone or cytokine) that binds to a receptor on the cell surface. This triggers the activation of JAK, which then activates STAT. The activated STAT proteins then move into the cell nucleus, where they influence the activity of certain genes.
Related Terms
- Janus kinase (JAK): A family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway.
- Signal Transducer and Activator of Transcription (STAT): A family of transcription factors that regulate gene expression in response to cytokines and growth factors.
- Cytokine: A type of protein that is important in cell signaling. They are released by cells and affect the behavior of other cells.
- Cell receptor: A protein on the cell surface or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates a response in the cell.
- Cell nucleus: The central part of a cell that contains most of its genetic material, including chromosomes and DNA.
See Also
External links
- Medical encyclopedia article on JAK-STAT signaling pathway
- Wikipedia's article - JAK-STAT signaling pathway
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