Intramembranous ossification
Intramembranous Ossification
Intramembranous ossification (pronunciation: in-tra-mem-bran-ous os-si-fi-ca-tion) is a process of bone formation where the bone tissue forms directly within mesenchyme or fibrous connective tissue. This process is one of the two methods of bone development and is responsible for the formation of the flat bones of the skull, the mandible, and the clavicles.
Etymology
The term 'intramembranous ossification' is derived from the Latin words 'intra' meaning 'within', 'membrana' meaning 'membrane', and 'ossificare' meaning 'to make bone'.
Process
Intramembranous ossification begins when mesenchymal cells aggregate together, differentiate into osteoblasts, and begin to secrete the organic components of the bone matrix. As the matrix surrounds and isolates the osteoblasts, they become osteocytes, the cells of mature bone. The formation of bone spicules proceeds outward from the ossification center in small struts. These struts join together, trapping blood vessels within the bone.
Related Terms
- Osteoblasts: Bone-forming cells that secrete the bone matrix.
- Osteocytes: Mature bone cells that maintain the bone matrix.
- Mesenchyme: Embryonic connective tissue from which all tissues and organs develop.
- Endochondral ossification: The other method of bone development, where the bone forms by replacing hyaline cartilage.
See Also
External links
- Medical encyclopedia article on Intramembranous ossification
- Wikipedia's article - Intramembranous ossification
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