Insulin Glargine
Insulin Glargine
Insulin Glargine (pronounced as in-su-lin glar-geen) is a long-acting insulin analog used to regulate the blood sugar levels in people with Type 1 diabetes and Type 2 diabetes. It is also known by its brand names Lantus, Basaglar, and Toujeo.
Etymology
The term "Insulin Glargine" is derived from its unique formulation. "Insulin" is a hormone produced by the pancreas that regulates the amount of glucose in the blood. "Glargine" is a modification of the word "large", referring to the longer duration of action of this insulin analog compared to regular human insulin.
Pharmacology
Insulin Glargine is a recombinant human insulin analog that is designed to have low solubility at neutral pH. After injection, it forms a precipitate in the subcutaneous tissue, from which small amounts are slowly released, resulting in a relatively constant concentration/time profile over 24 hours with no pronounced peak. This gives it a long duration of action and a relatively stable blood glucose-lowering effect.
Usage
Insulin Glargine is used to improve blood sugar control in adults and children with diabetes mellitus. It is used when diet and exercise alone does not result in good blood sugar control.
Side Effects
Like all medicines, Insulin Glargine can cause side effects, although not everybody gets them. Some common side effects include hypoglycemia (low blood sugar), allergic reactions, injection site reactions, and lipodystrophy (changes in the fatty tissue at the injection site).
See Also
External links
- Medical encyclopedia article on Insulin Glargine
- Wikipedia's article - Insulin Glargine
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