Histamine H3 receptor
Histamine H3 receptor
The Histamine H3 receptor (H3R) is a G-protein coupled receptor (GPCR) that belongs to the histamine receptor family. It is primarily found in the central nervous system (CNS) and to a lesser extent in the peripheral nervous system (PNS).
Pronunciation
His-ta-mine H3 re-cep-tor
Etymology
The term "Histamine" is derived from the Greek words "histos" meaning tissue and "amine" a type of organic compound. The "H3 receptor" part of the name refers to the third subtype of histamine receptors discovered.
Function
The Histamine H3 receptor plays a crucial role in the release and synthesis of neurotransmitters, including acetylcholine, serotonin, norepinephrine, and dopamine. It is involved in various physiological functions such as sleep-wake cycle regulation, cognitive processes, and appetite control.
Related Terms
- Histamine
- Histamine H1 receptor
- Histamine H2 receptor
- Histamine H4 receptor
- G-protein coupled receptor
- Neurotransmitter
- Central nervous system
- Peripheral nervous system
Pharmacology
Several antagonists and inverse agonists have been developed to target the Histamine H3 receptor. These drugs are being investigated for their potential use in treating various neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and narcolepsy.
External links
- Medical encyclopedia article on Histamine H3 receptor
- Wikipedia's article - Histamine H3 receptor
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