Goods

Goods Syndrome

Goods Syndrome (pronounced: /ɡʊdz/ /sɪndroʊm/) is a rare immunodeficiency disorder characterized by thymoma, hypogammaglobulinemia, low B-cell count, and an inverted CD4/CD8 ratio.

Etymology

The syndrome is named after Dr. Robert Good, an American physician who first described the condition in 1954.

Definition

Goods Syndrome is a type of primary immunodeficiency (PID) that is often associated with thymomas. Patients with Goods Syndrome have low levels of immunoglobulins, which are proteins that help the body fight off infections. This leads to a higher susceptibility to bacterial, viral, and fungal infections.

Symptoms

The symptoms of Goods Syndrome can vary greatly from person to person. However, common symptoms include recurrent infections, particularly of the respiratory tract, and chronic diarrhea. Other symptoms may include weight loss, fatigue, and skin infections.

Diagnosis

Diagnosis of Goods Syndrome is often challenging due to its rarity and the wide range of symptoms. It is typically diagnosed through a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests often show low levels of immunoglobulins and B cells, and an inverted CD4/CD8 ratio.

Treatment

Treatment for Goods Syndrome is primarily focused on managing symptoms and preventing infections. This may include immunoglobulin replacement therapy, antibiotics, and other supportive care measures.

Related Terms

• Immunodeficiency
• Thymoma
• Primary Immunodeficiency
• Immunoglobulin
• B cells
• CD4
• CD8

External links

• Medical encyclopedia article on Goods
• Wikipedia's article - Goods

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