Glyceroneogenesis

Glyceroneogenesis (pronunciation: gly·cer·o·neo·gen·e·sis) is a metabolic pathway which results in the production of glycerol 3-phosphate from precursors other than glucose.

Etymology

The term "Glyceroneogenesis" is derived from the words "glycerol" and "neo" meaning new, and "genesis" meaning creation. Thus, it refers to the creation of new glycerol.

Process

Glyceroneogenesis is a process that occurs primarily in the adipose tissue and the liver. It is a truncated version of gluconeogenesis that bypasses the steps in the gluconeogenesis pathway that are irreversible. The process begins with the conversion of pyruvate into phosphoenolpyruvate by the enzyme PEPCK. This is followed by a series of reactions that ultimately produce glycerol 3-phosphate.

Function

The primary function of glyceroneogenesis is to provide glycerol 3-phosphate for the re-esterification of free fatty acids in the adipose tissue. This process is particularly important during periods of fasting, when the rate of lipolysis is high.

Related Terms

Gluconeogenesis: The metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates.
PEPCK: An enzyme in the lyase family used in the metabolic pathway of gluconeogenesis.
Pyruvate: The end product of glycolysis, which is converted into acetyl coenzyme A that enters the citric acid cycle.
Phosphoenolpyruvate: A compound that plays a key role in glycolysis and gluconeogenesis.
Adipose tissue: A loose connective tissue composed mostly of fat cells.
Liver: A large, meaty organ that sits on the right side of the belly, which has many functions in the body including detoxification, protein synthesis, and the production of biochemicals necessary for digestion.

External links

Medical encyclopedia article on Glyceroneogenesis
Wikipedia's article - Glyceroneogenesis

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Glyceroneogenesis