Glutamate carboxypeptidase II
Glutamate Carboxypeptidase II
Glutamate Carboxypeptidase II (pronounced: glu-ta-mate car-boxy-pep-ti-dase two), also known as GCPII or N-acetylated-alpha-linked acidic dipeptidase (pronounced: N-ace-tyl-ated-alpha-linked acid-ic di-pep-ti-dase), is an enzyme that in humans is encoded by the FOLH1 gene.
Etymology
The term "Glutamate Carboxypeptidase II" is derived from its function. "Glutamate" refers to the amino acid that the enzyme acts upon, "Carboxypeptidase" is a type of enzyme that cleaves the carboxyl group, and "II" indicates that it is the second enzyme of this type to be discovered.
Function
Glutamate Carboxypeptidase II is a type of Metallopeptidase that is involved in the metabolism of the neurotransmitter Glutamate. It is responsible for the hydrolysis of N-acetyl-L-aspartyl-L-glutamate (NAAG) into N-acetyl-aspartate and glutamate. This enzyme plays a crucial role in the glutamate signaling pathway, which is involved in learning, memory, and neurodegeneration.
Clinical Significance
Alterations in the function of Glutamate Carboxypeptidase II have been implicated in a variety of neurological disorders, including Schizophrenia, Alzheimer's disease, and Chronic pain. Inhibitors of this enzyme, such as ZJ-43 and 2-PMPA, are being investigated for their potential therapeutic applications in these conditions.
Related Terms
External links
- Medical encyclopedia article on Glutamate carboxypeptidase II
- Wikipedia's article - Glutamate carboxypeptidase II
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