Free-radical theory of aging
Free-radical theory of aging
The Free-radical theory of aging (pronunciation: free-rad-i-cal theo-ry of a-ging) is a biological theory that explains the process of aging based on the activity of free radicals in the body.
Etymology
The term "free-radical theory of aging" was first coined by Denham Harman in 1956. The term "free radical" refers to a molecule with an unpaired electron, making it highly reactive. The "theory of aging" refers to the hypothesis that free radicals cause damage to cells over time, leading to aging.
Definition
The Free-radical theory of aging posits that the accumulation of damage caused by free radicals over time leads to the physiological and anatomical changes associated with aging. Free radicals are unstable molecules that can cause damage to cells, proteins, and DNA. This damage, also known as oxidative stress, is believed to be a major factor in the aging process and the development of age-related diseases.
Related Terms
- Oxidative Stress: A condition resulting from an imbalance between the production of free radicals and the body's ability to counteract their harmful effects.
- Antioxidants: Substances that can prevent or slow damage to cells caused by free radicals.
- Mitochondrial Theory of Aging: A theory that suggests that damage to mitochondria, the powerhouses of cells, leads to aging.
- DNA Damage Theory of Aging: A theory that proposes that aging is primarily caused by an accumulation of damage to DNA.
See Also
External links
- Medical encyclopedia article on Free-radical theory of aging
- Wikipedia's article - Free-radical theory of aging
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