Fondaparinux
Fondaparinux
Fondaparinux (pronounced: fon-da-pa-ri-nux) is a synthetic anticoagulant medication used primarily to prevent deep vein thrombosis (DVT) and pulmonary embolism (PE).
Etymology
The name "Fondaparinux" is derived from its chemical structure. It is a synthetic pentasaccharide, hence the suffix "-parinux". The prefix "Fonda-" is arbitrary and does not have a specific meaning.
Usage
Fondaparinux is used to prevent and treat deep vein thrombosis and pulmonary embolism. It is also used in the management of acute coronary syndrome (ACS) and in the prevention of clotting during hemodialysis.
Mechanism of Action
Fondaparinux works by inhibiting Factor Xa, a key enzyme in the coagulation cascade. By inhibiting Factor Xa, Fondaparinux prevents the formation of thrombin, thereby preventing the formation of blood clots.
Side Effects
Common side effects of Fondaparinux include bleeding, anemia, and thrombocytopenia. Rare but serious side effects include severe bleeding, heparin-induced thrombocytopenia (HIT), and osteoporosis.
Related Terms
- Anticoagulant
- Deep vein thrombosis
- Pulmonary embolism
- Acute coronary syndrome
- Hemodialysis
- Factor Xa
- Coagulation cascade
- Thrombin
- Heparin-induced thrombocytopenia
- Osteoporosis
External links
- Medical encyclopedia article on Fondaparinux
- Wikipedia's article - Fondaparinux
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