Factor xiii
Factor XIII
Factor XIII (pronounced as "Factor Thirteen"), also known as Fibrin Stabilizing Factor (FSF), is a enzyme that plays a crucial role in the blood coagulation process.
Pronunciation
Factor XIII: /ˈfæk.tər θɜːrˈtiːn/
Etymology
The term "Factor XIII" is derived from the classification of blood clotting factors. It is the thirteenth identified factor that plays a role in the process of blood coagulation.
Function
Factor XIII is activated by thrombin and calcium ions to become Factor XIIIa, an enzyme that crosslinks fibrin into a stable clot. In the absence of Factor XIII, a clot can form but it is not stable and is easily broken down.
Related Terms
- Coagulation: The process by which blood changes from a liquid to a gel, forming a clot.
- Thrombin: An enzyme in blood plasma that causes the clotting of blood by converting fibrinogen to fibrin.
- Fibrin: A fibrous protein involved in the clotting of blood.
- Calcium ion: A divalent metal cation, essential for various bodily functions, including blood clotting.
- Enzyme: A substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.
Disorders
Deficiency of Factor XIII, known as Factor XIII deficiency, is a rare genetic disorder characterized by abnormal blood clotting that can lead to excessive bleeding.
Treatment
Treatment for Factor XIII deficiency involves regular infusions of Factor XIII concentrate to prevent bleeding episodes.
External links
- Medical encyclopedia article on Factor xiii
- Wikipedia's article - Factor xiii
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