EXT1
EXT1
EXT1 (/ɛks tiː wʌn/), also known as Exostosin-1, is a protein that in humans is encoded by the EXT1 gene. It is a key component in the biosynthesis of heparan sulfate, a type of glycosaminoglycan.
Etymology
The term "EXT1" is derived from the word "Exostosin", which is a combination of "exostosis" and the suffix "-in" used in protein nomenclature. "Exostosis" is a medical term for a benign growth on the surface of a bone, and "-in" is a common suffix used to denote proteins.
Function
The EXT1 gene provides instructions for making an enzyme that helps construct heparan sulfate. This complex sugar molecule is attached to proteins to form proteoglycans, which are essential for communication between cells and for structuring the spaces between them.
Related Terms
- EXT2: Another gene involved in the production of heparan sulfate.
- Multiple exostoses: A condition characterized by multiple bone growths (exostoses) and caused by mutations in the EXT1 or EXT2 gene.
- Heparan sulfate proteoglycans: Proteins to which heparan sulfate is attached, playing a crucial role in cell communication and structuring cell environments.
See Also
External links
- Medical encyclopedia article on EXT1
- Wikipedia's article - EXT1
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