Dopamine beta-hydroxylase
Dopamine beta-hydroxylase
Dopamine beta-hydroxylase (pronounced: doh-puh-meen bay-tuh hy-drox-uh-lase), also known as DBH, is an enzyme that catalyzes the conversion of dopamine to norepinephrine.
Etymology
The term "Dopamine beta-hydroxylase" is derived from the name of the substrate it acts upon, dopamine, and its function as a beta-hydroxylase enzyme. The term "dopamine" is derived from the chemical compound 3,4-dihydroxyphenethylamine, and "beta-hydroxylase" refers to the type of reaction it catalyzes, specifically the addition of a hydroxyl group at the beta position of the substrate.
Function
Dopamine beta-hydroxylase is a crucial enzyme in the catecholamine biosynthetic pathway. It is responsible for the conversion of dopamine, a key neurotransmitter, into norepinephrine, another important neurotransmitter. This conversion is a critical step in the synthesis of norepinephrine from tyrosine.
Related Terms
- Enzyme: A protein that acts as a biological catalyst to speed up a chemical reaction.
- Dopamine: A type of neurotransmitter, a chemical messenger that transmits signals in the brain and other areas of the body.
- Norepinephrine: A neurotransmitter and hormone that is involved in the body's stress response.
- Catecholamine: A group of neurotransmitters, including dopamine, norepinephrine, and epinephrine, that have similar structures and are involved in various physiological responses such as stress and fear responses.
External links
- Medical encyclopedia article on Dopamine beta-hydroxylase
- Wikipedia's article - Dopamine beta-hydroxylase
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