Des(1-3)IGF-1
Des(1-3)IGF-1
Des(1-3)IGF-1 (pronounced as "des one to three IGF-one"), also known as Des1-3 IGF-1 or Des IGF-1, is a truncated variant of IGF-1 (Insulin-like Growth Factor 1).
Etymology
The term Des(1-3)IGF-1 is derived from the fact that it lacks the first three amino acids at the N-terminus of the full-length IGF-1 molecule. The prefix "Des" is short for "deletion", indicating the absence of these amino acids.
Function
Des(1-3)IGF-1 is a potent growth factor that stimulates the growth and proliferation of cells. It is more potent than the full-length IGF-1 due to its higher affinity for the IGF-1 receptor, which results in increased biological activity.
Related Terms
- IGF-1: A protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s.
- IGF-1 receptor: A protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2.
- Growth factor: A naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.
External links
- Medical encyclopedia article on Des(1-3)IGF-1
- Wikipedia's article - Des(1-3)IGF-1
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