Defibrotide sodium
Defibrotide Sodium
Defibrotide sodium (pronunciation: de-fib-ro-tide so-dee-um) is a medicinal drug used in the treatment of severe hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), particularly in patients following hematopoietic stem-cell transplantation (HSCT).
Etymology
The term "Defibrotide" is derived from its chemical structure. It is a polydeoxyribonucleotide, a type of polymer made up of deoxyribonucleotides. The "sodium" in its name refers to the sodium salt form of the drug.
Usage
Defibrotide sodium is used to treat severe hepatic VOD/SOS in adults and children who have undergone HSCT. This condition is a potentially life-threatening complication of HSCT, and Defibrotide sodium has been shown to significantly improve survival rates in these patients.
Mechanism of Action
Defibrotide sodium works by protecting the cells lining the blood vessels in the liver from damage, reducing inflammation and clotting, and breaking down existing blood clots. It is a unique class of drug known as a fibrinolytic agent.
Related Terms
- Hepatic veno-occlusive disease: A condition characterized by the blockage of small veins in the liver.
- Hematopoietic stem-cell transplantation: A procedure that replaces damaged or destroyed bone marrow with healthy bone marrow stem cells.
- Fibrinolytic: A type of drug that breaks down blood clots.
See Also
External links
- Medical encyclopedia article on Defibrotide sodium
- Wikipedia's article - Defibrotide sodium
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