Chromoplexy
Chromoplexy
Chromoplexy (pronounced: kro-mo-plek-see) is a complex genomic rearrangement process that occurs in cancer cells.
Etymology
The term "Chromoplexy" is derived from the Greek words "chroma" meaning color and "plexis" meaning braiding or twisting. This term was coined to describe the complex, interwoven pattern of genomic rearrangements observed in cancer genomes.
Definition
Chromoplexy is a process that involves multiple simultaneous double-strand DNA breaks and subsequent repair, leading to complex genomic rearrangements. This process is thought to be a major driver of tumorigenesis in several types of cancer, including prostate, lung, and colorectal cancers.
Related Terms
- Genomic Rearrangement: A type of mutation that involves a change in the order of the DNA sequence on a chromosome.
- Tumorigenesis: The process by which normal cells are transformed into cancer cells.
- Double-Strand Break: A type of DNA damage where both strands in the double helix are severed.
- Prostate Cancer: A type of cancer that occurs in the prostate — a small walnut-shaped gland in men that produces the seminal fluid that nourishes and transports sperm.
- Lung Cancer: A type of cancer that begins in the lungs and is often associated with smoking.
- Colorectal Cancer: A type of cancer that begins in the colon or rectum, part of the body's digestive system.
See Also
External links
- Medical encyclopedia article on Chromoplexy
- Wikipedia's article - Chromoplexy
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