Caloric restriction mimetic
Caloric Restriction Mimetic
Caloric restriction mimetic (pronunciation: kuh-LOHR-ik re-STRIK-shun mim-ET-ik) is a type of pharmacological agent that can mimic the metabolic, physiological, and healthspan benefits of caloric restriction without the need to reduce food intake.
Etymology
The term "caloric restriction mimetic" is derived from the concept of "caloric restriction" and the word "mimetic". "Caloric restriction" refers to the reduction of calorie intake without malnutrition, while "mimetic" is derived from the Greek word "mimetikos", meaning "imitative".
Definition
Caloric restriction mimetics are compounds that can mimic the biochemical and functional effects of caloric restriction, leading to improved health and lifespan. These compounds work by activating the same cellular pathways as caloric restriction, including those involved in autophagy, sirtuin activation, and AMP-activated protein kinase (AMPK) activation.
Related Terms
- Autophagy: A cellular process that breaks down and recycles unnecessary or dysfunctional components.
- Sirtuin: A family of proteins that regulate cellular health.
- AMP-activated protein kinase (AMPK): An enzyme that plays a role in cellular energy homeostasis.
- Metabolic pathway: A series of chemical reactions in a cell that build up or break down molecules for cellular processes.
- Physiological process: The processes and functions of the body.
- Healthspan: The period of life during which a person is generally healthy and free from serious disease.
See Also
External links
- Medical encyclopedia article on Caloric restriction mimetic
- Wikipedia's article - Caloric restriction mimetic
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