C-Met
C-Met
C-Met (pronounced: see-met), also known as hepatocyte growth factor receptor (pronounced: hep-uh-toe-site growth factor re-cep-tor), is a protein that in humans is encoded by the MET gene.
Etymology
The term "C-Met" is derived from the words "cellular" and "mesenchymal-epithelial transition factor", which is the full form of the MET gene. The MET gene provides instructions for making the C-Met protein.
Function
C-Met is a receptor tyrosine kinase that is produced by cells of the liver. It is essential for embryonic development, organogenesis and wound healing. The C-Met protein plays a crucial role in cell proliferation, cell survival, angiogenesis, and cell motility.
Related Terms
- Hepatocyte Growth Factor (HGF): A paracrine cellular growth, motility and morphogenic factor secreted by mesenchymal cells and primarily acting upon epithelial cells and endothelial cells, but also acting on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration, and in wound healing.
- Receptor Tyrosine Kinase (RTK): A high-affinity cell surface receptor for many polypeptide growth factors, cytokines, and hormones. RTKs are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
- Angiogenesis: The physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis.
- Cell Motility: Refers to the movements performed by cells, including the migration of cells, intracellular transport, and changes in cell shape.
External links
- Medical encyclopedia article on C-Met
- Wikipedia's article - C-Met
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