Bispecific antibody
Bispecific antibody (pronounced: bi-spe-ci-fic an-ti-bo-dy) is a type of antibody that has been engineered to combine two different antigen binding sites. This allows the antibody to simultaneously bind to two different types of antigens, potentially enhancing its therapeutic effect.
Etymology
The term "bispecific antibody" is derived from the Latin bis, meaning "twice", and the Greek specifikos, meaning "distinguishing". The term "antibody" comes from the Greek anti, meaning "against", and body, referring to a substance in the body.
Structure
Bispecific antibodies are typically composed of two different monoclonal antibodies that have been fused together. This can be achieved through a variety of methods, including genetic engineering and chemical conjugation. The resulting antibody retains the antigen-binding specificity of both parent antibodies.
Uses
Bispecific antibodies have a wide range of potential uses in medicine, particularly in the field of oncology. By binding to two different antigens, they can target cancer cells more specifically and effectively than traditional monoclonal antibodies. They are also being investigated for use in the treatment of autoimmune diseases and infectious diseases.
Related Terms
- Monoclonal antibody
- Antigen
- Genetic engineering
- Chemical conjugation
- Oncology
- Autoimmune diseases
- Infectious diseases
See Also
External links
- Medical encyclopedia article on Bispecific antibody
- Wikipedia's article - Bispecific antibody
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