Bioanalysis
Bioanalysis
Bioanalysis (pronounced: bio-anal-ysis, from the Greek words bios meaning "life" and analysis meaning "a detailed examination") is a sub-discipline of Analytical Chemistry that involves the quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and biotics (macromolecules, proteins, DNA, large molecule drugs, metabolites) in biological systems.
History
The term "bioanalysis" was first used in the late 20th century, coinciding with the development of sophisticated analytical techniques and instruments such as Mass Spectrometry and High-Performance Liquid Chromatography (HPLC).
Applications
Bioanalysis is applied in many important areas of scientific research, including Pharmacokinetics, Toxicology, and Clinical Chemistry. It is also crucial in the development of new drugs and in the monitoring of patient drug levels in clinical trials.
Techniques
Common techniques used in bioanalysis include:
- Mass Spectrometry (MS)
- High-Performance Liquid Chromatography (HPLC)
- Capillary Electrophoresis (CE)
- Gas Chromatography (GC)
- Nuclear Magnetic Resonance (NMR)
Related Terms
- Pharmacokinetics: The study of how drugs are absorbed, distributed, metabolized, and excreted by the body.
- Toxicology: The study of the adverse effects of chemicals on living organisms.
- Clinical Chemistry: The area of chemistry that is generally concerned with analysis of bodily fluids for diagnostic and therapeutic purposes.
- Xenobiotics: Foreign substances in the body, including drugs and environmental pollutants.
- Biotics: Living organisms, their actions, and processes in the body.
External links
- Medical encyclopedia article on Bioanalysis
- Wikipedia's article - Bioanalysis
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