Anti-LKM antibody
Anti-LKM antibody
Anti-LKM antibody (pronounced: an-tee el-kay-em an-ti-bod-ee) is a type of autoantibody that targets liver and kidney microsomal proteins. The term "Anti-LKM antibody" is derived from the words "anti" meaning against, "LKM" an abbreviation for Liver Kidney Microsomal, and "antibody" a protein produced by the body's immune system when it detects harmful substances.
Function
Anti-LKM antibodies are primarily associated with autoimmune hepatitis type 2 (AIH-2) and hepatitis C virus (HCV) infection. They are used as a diagnostic marker for these conditions.
Types
There are three types of Anti-LKM antibodies: Anti-LKM1, Anti-LKM2, and Anti-LKM3. Anti-LKM1 is the most common and is associated with AIH-2. Anti-LKM2 is associated with drug-induced hepatitis, while Anti-LKM3 is associated with HCV infection.
Detection
Anti-LKM antibodies can be detected through various laboratory tests, including enzyme-linked immunosorbent assay (ELISA), immunofluorescence (IF), and western blot.
Related Terms
- Autoantibody
- Autoimmune hepatitis
- Hepatitis C
- Enzyme-linked immunosorbent assay
- Immunofluorescence
- Western blot
External links
- Medical encyclopedia article on Anti-LKM antibody
- Wikipedia's article - Anti-LKM antibody
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