Alogliptin

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Information about Alogliptin

Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other oral hypoglycemic agents.

Liver safety of Alogliptin

Alogliptin has been reported to cause liver injury, but the characteristics and details of the injury have not been defined in the published literature.

Mechanism of action of Alogliptin

Alogliptin (al" oh glip' tin) is an inhibitor of dipeptidyl peptidase-4, which is the major enzyme responsible for the degradation of glucagon-like peptide-1 (GLP-1), an important gastrointestinal hormone (incretin) that increases glucose dependent insulin secretion by the pancreas. By prolonging the effect of GLP-1, alogliptin increases insulin levels and lowers blood glucose and helps in glycemic control in patients with type 2 diabetes.

FDA approval information for Alogliptin

Alogliptin was approved for use in the United States in 2013 and was the fourth DPP-4 inhibitor introduced into clinical practice.

Clinical use of Alogliptin

The current indications are for management of glycemic control in type 2 diabetes used in combination with diet and exercise, with or without other oral hypoglycemic agents or insulin.

Dosage and administration for Alogliptin

Alogliptin is available in tablets of 6.25, 12.5 and 25 mg under the brand name Nesina and in fixed combinations with metformin (12.5/500 mg and 12.5/1000 mg) under the name Kazano and with pioglitazone (various dose combinations) under the name Oseni. The typical dose of alogliptin in adults is 25 mg once daily.

Side effects of Alogliptin

Adverse reactions to alogliptin are not common, but may include headache, nausea, rash and hypersensitivity reactions. Hypoglycemia is uncommon with alogliptin alone (<1%), but occurs in higher rates when it is combined with other oral hypoglycemic agents. Alogliptin has also been linked to rare instances of acute pancreatitis that can be severe and even fatal.

Antidiabetics

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