Adaptive design (medicine)
Adaptive design (medicine)
Adaptive design (pronounced: /əˈdæptɪv dɪˈzaɪn/) in the field of medicine refers to a methodology that allows modifications to the design or statistical procedures of a clinical trial while it is ongoing, without undermining the validity and integrity of the trial. The concept of adaptive design originated from the field of statistics and has been increasingly applied in clinical research.
Etymology
The term "adaptive design" is derived from the English words "adaptive", meaning capable of adjusting to new conditions, and "design", referring to a plan or drawing produced to show the look and function of something before it is built or made. In the context of clinical trials, it refers to the design that is capable of adjusting to the new data or conditions that emerge during the course of the trial.
Types of Adaptive Design
There are several types of adaptive designs used in medical research, including:
- Adaptive randomization: The probability of treatment assignment changes according to patient characteristics or outcomes of patients already in the trial.
- Sample size re-estimation: The sample size may be adjusted based on interim analysis of trial data.
- Drop-the-loser design: In multi-arm trials, treatments that appear to be ineffective can be dropped during the trial.
- Group sequential design: Allows for early stopping of the trial for efficacy or futility.
Related Terms
See Also
External links
- Medical encyclopedia article on Adaptive design (medicine)
- Wikipedia's article - Adaptive design (medicine)
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