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Abacavir

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abacavir sulfate

A sulfate salt form of abacavir, a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.

US brand name

Ziagen

Information about Abacavir

Abacavir sulfate is a nucleoside analogue and reverse transcriptase inhibitor which is used in combination with other agents in the therapy of the human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). Abacavir is a rare cause of clinically apparent drug induced liver injury.

Mechanism of action of Abacavir

Abacavir (a bak' a vir) (cyclopropylaminopurinylcyclopentene: ABC) is a structural analogue of guanosine and acts by competing with naturally occurring nucleosides for incorporation into the HIV DNA strand during viral replication, causing inhibition of the viral polymerase and chain termination. Abacavir is indicated for the treatment of HIV infection in combination with other HIV medications such as lamivudine and zidovudine.

Dosage and administration for Abacavir

Abacavir is available generically and under the trade name Ziagen in a 20 mg/mL oral solution and a 300 mg oral tablet. Abacavir is also available in fixed combination with lamivudine as Epzicom and Kivexa, with zidovudine and lamivudine as Trizivir and with dolutegravir and lamivudine as Triumeq. The recommended dose of abacavir is 300 mg orally twice daily or 600 mg orally once daily in adults and 8 mg/kg orally twice daily in children larger than 15 kg, with a maximum daily dose of 300 mg.

FDA approval information for Abacavir

Abacavir was approved for use in the United States in 1998 and is currently used in many antiretroviral regimens. Common side effects include diarrhea, loss of appetite, nausea, headache, and fatigue.

Antiviral agents

Drugs for HIV Infection, in the Subclass Antiretroviral Agents

Drugs for Hepatitis B

Drugs for Hepatitis C

HCV NS5A Inhibitors

HCV NS5B (Polymerase) Inhibitors

HCV Protease Inhibitors

Combination Therapies

Drugs for Herpes Virus Infections (HSV, CMV, others)

Drugs for Influenza


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