APOBEC3G
APOBEC3G
APOBEC3G (pronounced as A-P-O-B-E-C-Three-G), also known as apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G, is a human gene.
Etymology
The term APOBEC3G is an acronym derived from Apolipoprotein B mRNA Editing enzyme, Catalytic polypeptide-like 3G.
Function
APOBEC3G is a member of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) protein family. This family of proteins is involved in the innate immune response to viral infection, particularly retroviruses like HIV. APOBEC3G has been found to inhibit the replication of HIV by causing hypermutation of the viral genome.
Clinical Significance
APOBEC3G has been studied extensively for its role in HIV infection. It is one of the host restriction factors that can inhibit HIV-1 replication. However, the HIV-1 protein Vif (Viral infectivity factor) can counteract this restriction by promoting the degradation of APOBEC3G.
Related Terms
- APOBEC: A family of proteins that includes APOBEC3G and is involved in the innate immune response to viral infection.
- HIV: Human Immunodeficiency Virus, the virus that causes AIDS. APOBEC3G can inhibit the replication of this virus.
- Vif: Viral infectivity factor, a protein produced by HIV-1 that can counteract the restriction of APOBEC3G.
External links
- Medical encyclopedia article on APOBEC3G
- Wikipedia's article - APOBEC3G
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